Gum Disease Could Drive Alzheimer’s

Gum Disease Could Drive Alzheimer’s

Gum Disease Could Drive Alzheimer’s

Researchers have developed a novel approach that may one day make it possible to reverse memory loss, caused by Alzheimer's disease.

In the study, "Neuropsychological Deficit Profiles, Vascular Risk Factors, and Neuropathological Findings in Hispanic Older Adults with Autopsy-Confirmed Alzheimer's Disease" in the Journal of Alzheimer's Disease, autopsies of 14 Hispanic and 20 non-Hispanic persons were reviewed, all with autopsy-confirmed physiological evidence of AD.

This study presents new information about the possible link that a common mouth bacterium could have with Alzheimer's disease, and investigates a potential treatment.

"The impact of infectious agents previously associated with the development and progression of Alzheimer's disease, but a causal relationship is still inconclusive".

According to Axel Montagne, an assistant professor of research physiology and neuroscience at Keck, successful diagnoses of Alzheimer's will lead to advances in medical technology to treat Parkinson's disease, Huntington's disease and, most notably, amyotrophic lateral sclerosis. In both, a lack of sleep was found to produce increased levels of the protein tau, which is linked to Alzheimer's disease.

Lynch mentioned that despite "significant funding and the best efforts of academic, industry and advocacy communities, clinical progress against Alzheimer's has been frustratingly slow". So far, there is no cure for the disease.

Alzheimer's disease, an irreversible and progressive brain disorder that leads to memory loss and diminished thinking skills, affects at least 5 million Americans.

Many of us will know someone living with dementia, or their families and friends who are having to cope with what can be quite distressing situations of seeing their loved ones affected in this way.

The British Dental Association has used the news to remind the Department of Health on the importance of oral health.

They also showed that when genetically modified mice who were predisposed to Alzheimer's were infected with P. gingivalis, the bacterium ended up in their brain and that this was associated with increased levels of amyloid protein.

Four forms of Dementia are prevalent resulting in the decline of the brain including Alzheimer's, Vascular Dementia, Dementia with Lewy Bodies and Frontotemporal Dementia.

'But the evidence of causation hasn't been convincing.

An incredible discovery by medical researchers could change the treatment of Alzheimer's disease as we know it, now that a simple blood test could identify the condition over a decade before it sets in.

Trying to stop Pg buildup, the team designed small molecule inhibitors targeting the toxic enzyme gingipains. The protein demonstrates how much nerve cell loss you have in your brain - if you have more NfL in your blood, that means you have more brain damage.

The study pulled researchers closer to the role of sleeplessness in tau accumulation, clearing up some uncertainty about the protein's role. The drug cleared the infection from the animals' brains and reduced β-amyloid production and neurodegeneration. The new drug is now being tested on people in clinical trials.

Previous research has shown options for detecting Alzheimer's disease in its early stages.

Singhrao, who has also conducted research into the cause of Alzheimer's, had earlier discovered that the bacteria invade the brains of mice which had gum infections.

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